Methoxychlor-Induced Ovarian Follicle Toxicity in Mice: Dose and Exposure Duration-Dependent Effects
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چکیده
منابع مشابه
Dose-Dependent Estrous Cycle, Ovarian Follicles and Biochemical Contents Reversal in Albino Mice after Exposure to Mancozeb.
Mancozeb, a fungicide of a manganese-zinc ethylenebisdithio-carbamate (EBDC), was administered by gavage at doses of 200, 400, 600 and 800 mg/kg/day to female virgin mice for 30 days. The mice were autopsied on 31st day. Mice were also treated with similar doses for a period of 30 days and the treatment was withdrawn for a further period of 30 days for reversible study. The mice were autopsied...
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TCDD, a highly toxic lipophilic Dioxin, causes many health problems in animals including human when exposed through dietary intake of fat. Present communication reports in vivo dose and exposure duration dependent cellular toxicity of environmentally available concentration of TCDD to few lysosomal enzymes in mice kidney. The study tests two hypotheses (a) environmentally available low concentr...
متن کاملdose-dependent estrous cycle, ovarian follicles and biochemical contents reversal in albino mice after exposure to mancozeb.
mancozeb, a fungicide of a manganese-zinc ethylenebisdithio-carbamate (ebdc), was administered by gavage at doses of 200, 400, 600 and 800 mg/kg/day to female virgin mice for 30 days. the mice were autopsied on 31st day. mice were also treated with similar doses for a period of 30 days and the treatment was withdrawn for a further period of 30 days for reversible study. the mice were autopsied ...
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The pesticide methoxychlor (MXC) is a reproductive toxicant that targets antral follicles of the mammalian ovary. Cytochrome P450 enzymes metabolize MXC to mono-OH MXC (1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane [mono-OH]) and bis-OH MXC (1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane [HPTE]), two compounds that are proposed to be more toxic than the parent compound, can inte...
متن کاملPerinatal Exposure to Low-Dose Methoxychlor Impairs Testicular Development in C57BL/6 Mice
Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand for the risk assessment of offspring after maternal exposure to low doses of MXC. In this study, pregnant mice (F0) w...
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ژورنال
عنوان ژورنال: Birth Defects Research Part B: Developmental and Reproductive Toxicology
سال: 2012
ISSN: 1542-9733
DOI: 10.1002/bdrb.21007